Mast Cells are the oldest and one the most crucial immune cells that are distributed in all tissues and organs including, for example, the gastrointestinal tract, skin, lungs, skin, and cardio-vascular system. Mast cells play a key role in orchestrating our immune system with more than 200 receptors and the storage, formation and selective (differential) release of more than 800 different mediators.

Disorders of the mast cell function, especially excessive and abnormal activation (more and more driven by polygenetic and epigenetic dysregulation), lead to severe, often chronic diseases of the human organism in the areas of immunology and inflammation throughout all areas of the body.

Mast cell-driven diseases have a high unmet medical need affecting a significant number of patients, for example, chronic urticaria, asthma, COPD, allergic rhinitis, allergic contact dermatitis, IBS / IBD, food allergies, fibrotic diseases such as NASH and IPF, and several neuroinflammation diseases.

Mast cell-driven diseases most certainly includes Systemic Mast Cell Activation Disease (MCAD) with it’s rare disease variant Systemic Mastocytosis, as well as, a high number of patients with diagnosed with Mast Cell Activation Syndrome (MCAS) featuring often widespread systemic symptoms. Depending on the individual occurrence and severity of symptoms patients with MCAS are often diagnosed with chronic illnesses such as fibromyalgia, allergic asthma, chronic lyme disease, interstitial cystitis, various forms of allergy, and recently also long covid.