It would be absurd, of course, to think the dysregulated mast cell accounts for all chronic illnesses, however, over the past decade, increasing evidence has been emerging of important, even critical, roles for mast cell activation in the pathogenesis of a wide array of chronic illnesses.
Abnormal increased mast cell activity often combined with abnormal accumulation of mast cells has therefore been more and more recognized as cause or amplifier for a wide range of chronic inflammatory and immune system illnesses and being referred to as Modern Epidemic of Chronic Illness (Afrin, B. Lawrence, Mast cell activation disease and the modern epidemic of chronic inflammatory disease, Translational Research, 2016 [1,2]).
With the rapidly growing understanding and diagnosis of the respective mast-cell related diseases, the awareness and medical need is growing urgently with currently no satisfying treatment.
- Afrin, B. Lawrence, Mast cell activation disease and the modern epidemic of chronic inflammatory disease, translational research, Volume 174, August 2016, Pages 33-59
- Afrin, B. Lawrence, Never bet against occam: Mast cell activation disease and the modern epidemics of chronic illness and medical complexity, 2016, Sisters Media, LLC