IRRITABLE BOWEL SYNDROME
In the last decade, scientific and medical evidence has clearly demonstrated a crucial role of mast cell activation in the pathophysiology of IBS. Several studies have clearly shown that estimated 75% of patients with Irritable Bowel Syndrome (IBS-Diarrhea / Pain) have abnormal activated mast cells – and partially increased number of mast cells – in their gastrointestinal tract. The abnormal activated mast cells are directly related to visceral hypersensitivity, abdominal pain, diarrhea frequency and further IBS symptoms. Patients fulfilling criteria for therapy-resistant IBS are commonly found to suffer from mast cell activation disease.
The activation of mast cells participates in multiple pathophysiological processes of IBS (see graphic):
- Barrier disruption: regulating epithelial permeability via acting on tight junction.
- Secretion disorder: regulating epithelial water and ion transport.
- Inflammation: regulating blood flow and endothelial functions, as well as immunomodulation, inflammation, and defense against microbes.
- Dysmotility: regulating intestinal peristalsis.
- Visceral pain: regulating function of visceral afferent and sensation via neuro-immune mechanisms.
So far, despite immense research therapeutic options have not yet shown significant progress since they target symptoms but not the underlying root cause leading to an urgent need for new therapies targeting mast cells in IBS. Our novel mast cell therapy could for the first-time provide a cause-related and highly effective therapy for IBS.
IBS has an estimated prevalence of 412 million patients worldwide with an estimated 34 million diagnosed patients in the major markets.
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